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1

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

Lesnefsky, Edward J., Chen, Qun, Tandler, Bernard, Hoppel, Charles L.

Journal:

Annual Review of Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.96 MB

english, 2017

2

Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure

Edward J. Lesnefsky, Shadi Moghaddas, Bernard Tandler, Janos Kerner, Charles L. Hoppel

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2001

Language:

english

File:

PDF, 628 KB

english, 2001

3

71 Ischemic damage to the electron transport chain increases the production of reactive oxygen species from isolated rat heart mitochondria

Qun Chen, Shadi Moghaddas, Charles L. Hoppel, Edward J. Lesnefsky

Journal:

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

4

70 Quinol type compound in cytochrome c preparations leads to non-enzymatic reduction of cytochrome c during the measurement of complex III activity

Shadi Moghaddas, Anne M. Distler, Charles L. Hoppel, Edward J. Lesnefsky

Journal:

Year:

2007

Language:

english

File:

PDF, 44 KB

english, 2007

5

72 Myocardial ischemia does not alter electron transport chain supercomplexes

Shadi Moghaddas, Edward J. Lesnefsky

Journal:

Year:

2007

Language:

english

File:

PDF, 43 KB

english, 2007

6

Quinol type compound in cytochrome c preparations leads to non-enzymatic reduction of cytochrome c during the measurement of complex III activity

Shadi Moghaddas, Anne M. Distler, Charles L. Hoppel, Edward J. Lesnefsky

Journal:

Year:

2008

Language:

english

File:

PDF, 699 KB

english, 2008

7

Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

Karol Szczepanek, Qun Chen, Andrew C. Larner, Edward J. Lesnefsky

Journal:

Year:

2012

Language:

english

File:

PDF, 784 KB

english, 2012

8

Blockade of electron transport before ischemia provides an additive protection in bcl-2 overexpressor mice following prolonged ischemia–reperfusion

Aijun Xu, Karo Szczepanek, Ying Hu, Qun Chen, Edward J. Lesnefsky

Journal:

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

9

Partial inhibition of complex I does not prevent reverse flow-induced ROS generation

Thomas Ross, Karol Szczepanek, Ying Hu, Qun Chen, Edward J. Lesnefsky

Journal:

Year:

2012

Language:

english

File:

PDF, 85 KB

english, 2012

10

Chronic treatment with the long acting phosphodiesterase-5 inhibitor, tadalafil, decreases mitochondrial damage in diabetic mice

Hema S. Aluri, Sai S. Koka, Edward J. Lesnefsky, Rakesh C. Kukreja

Journal:

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

11

Cardiac injury: Role of mitochondrial calpain 1 activation

Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J., Chen, Qun

Journal:

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

12

Cardiac endoplasmic reticulum stress and permeability transition opening

Thompson, Jeremy, Hu, Ying, Chen, Qun, Lesnefsky, Edward J.

Journal:

Year:

2015

Language:

english

File:

PDF, 55 KB

english, 2015

13

Absence of microRNA-155 augments cardiac injury during ischemia–reperfusion

Szczepanek, Karol, Thompson, Jeremy, Hu, Ying, Xu, Aijun, Chen, Qun, Salloum, Fadi N., Lesnefsky, Edward J.

Journal:

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

14

Localization of calpain 1 within mitochondria

Chen, Qun, Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J.

Journal:

Year:

2015

Language:

english

File:

PDF, 64 KB

english, 2015

15

Cardiac ischemia: Electron transport chain damages intermediary metabolism

Younus, Masood, Thompson, Jeremy, Hu, Ying, Chen, Qun, Hollander, John F., Lesnefsky, Edward J.

Journal:

Year:

2015

Language:

english

File:

PDF, 45 KB

english, 2015

16

Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion

Chen, Qun, Younus, Masood, Thompson, Jeremy, Hu, Ying, Hollander, John M., Lesnefsky, Edward J.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2018

Language:

english

File:

PDF, 847 KB

english, 2018

17

Decreased Cytochrome c Oxidase Subunit VIIa in Aged Rat Heart Mitochondria: Immunocytochemistry

Hisashi Fujioka, Shadi Moghaddas, Deborah G. Murdock, Edward J. Lesnefsky, Bernard Tandler, Charles L. Hoppel

Journal:

The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology

Year:

2011

Language:

english

File:

PDF, 2.10 MB

english, 2011

18

Cough-Cardiopulmonary resuscitation in the cardiac catheterization laboratory: Hemodynamics during an episode of prolonged hypotensive ventricular tachycardia

Dr. Brian Miller, Edward Lesnefsky, Theresa Heyborne, Betty Schmidt, Kathy Freeman, Susan Breckinridge, Kathleen Kelley, David Mann, Michael Reiter

Journal:

Catheterization and Cardiovascular Interventions

Year:

1989

Language:

english

File:

PDF, 351 KB

english, 1989

19

Safety of cardiac catheterization via peripheral vascular grafts

Edward J. Lesnefsky, Frank P. Carrea, Bertron M. Groves

Journal:

Catheterization and Cardiovascular Interventions

Year:

1993

Language:

english

File:

PDF, 386 KB

english, 1993

20

Separation and Quantitation of Phospholipids and Lysophospholipids by High-Performance Liquid Chromatography

Edward J. Lesnefsky, Maria S.K. Stoll, Paul E. Minkler, Charles L. Hoppel

Journal:

Analytical Biochemistry

Year:

2000

Language:

english

File:

PDF, 94 KB

english, 2000

21

Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance inEscherichia coli

Jeremy J Minty, Ann A Lesnefsky, Fengming Lin, Yu Chen, Ted A Zaroff, Artur B Veloso, Bin Xie, Catie A McConnell, Rebecca J Ward, Donald R Schwartz, Jean-Marie Rouillard, Yuan Gao, Erdogan Gulari, Xia

Journal:

Microbial Cell Factories

Year:

2011

Language:

english

File:

PDF, 5.08 MB

english, 2011

22

CT appearance of calcified tumor thrombus in the inferior vena cava

Mary C. Olson, Terrence C. Demos, Mary H. Lesnefsky

Journal:

Abdominal Imaging

Year:

1993

Language:

english

File:

PDF, 740 KB

english, 1993

23

Superoxide dismutase decreases early reperfusion release of conjugated dienes following regional canine ischemia

E. J. Lesnefsky, P. M. Fennessey, K. M. Van Benthuysen, I. F. McMurtry, V. L. Travis, L. D. Horwitz

Journal:

Basic Research in Cardiology

Year:

1989

Language:

english

File:

PDF, 357 KB

english, 1989

24

Re: Pseudostenosis in the peripheral circulation

Mary H. Lesnefsky, Edward J. Lesnefsky

Journal:

CardioVascular and Interventional Radiology

Year:

1996

Language:

english

File:

PDF, 306 KB

english, 1996

25

Letter to the Editor

Mary H. Lesnefsky, M.D., Edward J. Lesnefsky, M.D.

Journal:

CardioVascular and Interventional Radiology

Year:

1996

Language:

english

File:

PDF, 94 KB

english, 1996

26

A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection

Ludovic Gomez, Melanie Paillard, Megan Price, Qun Chen, Geoffrey Teixeira, Sarah Spiegel, Edward J. Lesnefsky

Journal:

Basic Research in Cardiology

Year:

2011

Language:

english

File:

PDF, 649 KB

english, 2011

27

Why have we failed to show that effective treatment of depression in patients with comorbid coronary heart disease improves cardiac outcome?

Walter Victor R. Vieweg, Mehrul Hasnain, Edward J. Lesnefsky, Ananda K. Pandurangi

Journal:

Psychiatry and Clinical Neurosciences

Year:

2011

Language:

english

File:

PDF, 36 KB

english, 2011

28

Atrial natriuretic peptide kinetic studies in patients with cardiac dysfunction

Hensen, Johannes, Abraham, William T, Lesnefsky, Edward J, Levenson, Benny, Groves, Bertron M, Schröder, Klaus, Schrier, Robert W, Dürr, Jacques

Journal:

Kidney International

Year:

1992

Language:

english

File:

PDF, 633 KB

english, 1992

29

Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart

Charles L. Hoppel, Shadi Moghaddas, Edward J. Lesnefsky

Journal:

Year:

2002

Language:

english

File:

PDF, 60 KB

english, 2002

30

Left Ventricular Systolic Dysfunction Induced by Ventricular Ectopy: A Novel Model for Premature Ventricular Contraction-Induced Cardiomyopathy

Huizar, J. F., Kaszala, K., Potfay, J., Minisi, A. J., Lesnefsky, E. J., Abbate, A., Mezzaroma, E., Chen, Q., Kukreja, R. C., Hoke, N. N.

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2011

Language:

english

File:

PDF, 1.55 MB

english, 2011

31

Right ventricular ischemia and proximal right coronary artery narrowing indicated by exercise ST-segment elevation in lead V1

David W. Krueger, Edward J. Lesnefsky, Bertron M. Groves, Joann Lindenfeld

Journal:

The American Journal of Cardiology

Year:

1989

Language:

english

File:

PDF, 408 KB

english, 1989

32

Oxidation and release of glutathione from myocardium during early reperfusion

Edward J. Lesnefsky, John E. Repine, Lawrence D. Horwitz

Journal:

Free Radical Biology and Medicine

Year:

1989

Language:

english

File:

PDF, 472 KB

english, 1989

33

Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size

Stephen J. Portz, Edward J. Lesnefsky, Karyl M. VanBenthuysen, John E. Repine, Natalie B. Parker, Ivan F. McMurtry, Lawrence D. Horwitz

Journal:

Free Radical Biology and Medicine

Year:

1989

Language:

english

File:

PDF, 584 KB

english, 1989

34

Coronary endothelial dysfunction from ischemia and reperfusion: Effect of reactive oxygen metabolite scavengers

Lawrence D. Horwitz, Karyl M. VanBenthuysen, Frank M. Sheridan, Edward J. Lesnefsky, Ira M. Dauber, Ivan F. McMurtry

Journal:

Free Radical Biology and Medicine

Year:

1990

Language:

english

File:

PDF, 487 KB

english, 1990

35

Hydrogen peroxide decreases effective refractory period in the isolated heart

Edward J. Lesnefsky, Gerald R. Williams, Jeffrey D. Rubinstein, Terri S. Hogue, Lawrence D. Horwitz, Michael J. Reiter

Journal:

Free Radical Biology and Medicine

Year:

1991

Language:

english

File:

PDF, 573 KB

english, 1991

36

Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion

Jeffrey D. Rubinstein, Edward J. Lesnefsky, Richard M. Byler, Paul V. Fennessey, Lawrence D. Horwitz

Journal:

Free Radical Biology and Medicine

Year:

1992

Language:

english

File:

PDF, 626 KB

english, 1992

37

Reduction of infarct size by cell-permeable oxygen metabolite scavengers

Edward J. Lesnefsky

Journal:

Free Radical Biology and Medicine

Year:

1992

Language:

english

File:

PDF, 1.78 MB

english, 1992

38

Inability of dimenthylthiourea to limit tissue necrosis during acute myocardial infarction

Edward J. Lesnefsky

Journal:

Free Radical Biology and Medicine

Year:

1993

Language:

english

File:

PDF, 220 KB

english, 1993

39

Reply to Dr. Michael J. Kelner

Edward J. Lesnefsky

Journal:

Free Radical Biology and Medicine

Year:

1993

Language:

english

File:

PDF, 48 KB

english, 1993

40

Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat

Edward J. Lesnefsky, Charles L. Hoppel

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2008

Language:

english

File:

PDF, 564 KB

english, 2008

41

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore

Qun Chen, Edward J. Lesnefsky

Journal:

Year:

2011

Language:

english

File:

PDF, 518 KB

english, 2011

42

Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain

Qun Chen, Edward J. Lesnefsky

Journal:

Free Radical Biology and Medicine

Year:

2006

Language:

english

File:

PDF, 234 KB

english, 2006

43

Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: A DNA microarray study

Steve J. Schomisch, Deborah G. Murdock, Nasim Hedayati, Joseph L. Carino, Edward J. Lesnefsky, Brian L. Cmolik

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2005

Language:

english

File:

PDF, 307 KB

english, 2005

44

Structure of cristae in cardiac mitochondria of aged rat

Alessandro Riva, Bernard Tandler, Edward J. Lesnefsky, Gabriele Conti, Felice Loffredo, Edwin Vazquez, Charles L. Hoppel

Journal:

Mechanisms of Ageing and Development

Year:

2006

Language:

english

File:

PDF, 759 KB

english, 2006

45

Sensitivity of Protein Sulfhydryl Repair Enzymes to Oxidative Stress

David W Starke, Yuegang Chen, Chandra P Bapna, Edward J Lesnefsky, John J Mieyal

Journal:

Free Radical Biology and Medicine

Year:

1997

Language:

english

File:

PDF, 233 KB

english, 1997

46

Ischemic Injury to Mitochondrial Electron Transport in the Aging Heart: Damage to the Iron–Sulfur Protein Subunit of Electron Transport Complex III

Edward J. Lesnefsky, Tatyana I. Gudz, Catharina T. Migita, Masao Ikeda-Saito, Medhat O. Hassan, Peter J. Turkaly, Charles L. Hoppel

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 759 KB

english, 2001

47

Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria by Alteration of the Cytochrome c Binding Site

Edward J. Lesnefsky, Tatyana I. Gudz, Shadi Moghaddas, Catharina T. Migita, Masao Ikeda-Saito, Peter J. Turkaly, Charles L. Hoppel

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2001

Language:

english

File:

PDF, 203 KB

english, 2001

48

Thallium scintigraphic evidence of reversible myocardial ischemia caused by anomalous origin of the left main coronary artery from the anterior sinus of Valsalva

Edward J. Lesnefsky, Jose Pacheco, Kim Adcock, J.Kern Buckner, Karyl M. Van Benthuysen

Journal:

American Heart Journal

Year:

1987

Language:

english

File:

PDF, 2.06 MB

english, 1987

49

Effects of acute left anterior descending occlusion on regional myocardial blood flow and wall thickening in the presence of a circumflex stenosis in dogs

Joseph A. Gascho, Edward J. Lesnefsky, Maire S. Mahanes, Donald L. Kaiser, George A. Beller

Journal:

The American Journal of Cardiology

Year:

1984

Language:

english

File:

PDF, 1.23 MB

english, 1984

50

Early thrombosis of a porcine bioprosthesis in the aortic valve position

Edward J. Lesnefsky, Bertron M. Groves, George F. Woelfel, Ira M. Dauber, David N. Campbell

Journal:

The American Journal of Cardiology

Year:

1986

Language:

english

File:

PDF, 1.36 MB

english, 1986

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